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Hundreds of genes have now been linked to Autism
Knowing which ones matter most is the challenge
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By Peter Clark (Senior Editor, Autism Info Center) Thursday 19th February 2026 |
Researchers at the University of Aberdeen have created a detailed map showing when and where autism-linked genes are active during early brain development.
The study, published in Nature Communications, reveals that many of these genes function within the "extracellular matrix" (ECM)-the structural support system surrounding brain cells.
By analysing gene activity in over 213,000 cells from developing human brains, the team found that the ECM is not merely static scaffolding.
Instead, it acts as an active environment guiding how cells move and connect.
Crucially, the study identifies the early second trimester as a pivotal time for these genetic activities.
The findings challenge the traditional focus on neurons alone.
The data shows that non-neuronal cells significantly contribute to the ECM and potential developmental risks.
Dr Eunchai Kang, the study's senior author, noted that understanding this coordination is vital for grasping how the brain forms.
Co-author Dr Daniel Berg added that knowing which genes are active in specific cell types provides a clearer picture of how the brain is built.
This knowledge could eventually support the development of targeted therapies for neurodevelopmental conditions.
Source: Technology Networks (UK); University of Aberdeen (UK)
https://www.technologynetworks.com/genomics/news/
Further reading, listening and viewing...
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